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Article: (Beta)-carotene alters the morphology of NCI-H69 small cell lung cancer cells
- Article from:
- The Journal of Nutrition
- Article date:
- January 1, 2002
- Author:
CopyrightCopyright American Institute of Nutrition Jan 2002. Provided by ProQuest LLC. (Hide copyright information)
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Nutrition and Cancer-Research Communication
beta-Carotene Alters the Morphology of NCI-H69 Small Cell Lung Cancer Cells1
ABSTRACT The effect of beta-carotene on the morphology of NCI-H69 small cell lung cancer cells that had undergone beta-carotene-induced growth reduction (P < 0.05) was examined. The cells were grown at 1 x 10^sup 8^ cells/L and were cultured with or without 20 (mu)mol/L beta-carotene. The qualitative electron microscopic observations revealed that beta-carotene-treated cells contained more vacuoles than control cells not treated with beta-carotene. The quantitative image analysis showed a significantly smaller (P < 0.05) value of the nuclear roundness factor for ...