Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants

Genetics;  October 1, 2006 ;   Harris, Jasper; Lowden, Mia; Clejan, Iuval; Tzoneva, Monika; Et al;   787 words ...ABSTRACT DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate...arrest of the cell cycle and DNA repair. The C. elegans DNA damage response mutants mrt-2, hus-1, and clk-2(mn159) displayed...

DNA damage response

The Scientist;  November 17, 2003 ;   Elledge, Stephen J;   162 words ......whose abundance increased in response to DNA damage. I expected a recombinase but when I...replication was protected in response to DNA damage. This Northern blot figure shows how...gene goes up dramatically in response to DNA damage. Using the promoter from this and related...

Prompt and delayed nonsteroidal anti-inflammatory drug-photoinduced DNA...

Photochemistry and Photobiology;  April 1, 2003 ;   Vinette, Anne L; McNamee, James P; Bellier, Pascale V; McLean, J R N; Scaiano, J C;   787 words ......Nonsteroidal Anti-inflammatory Drug-photoinduced DNA Damage in Peripheral Blood Mononuclear Cells...anti-inflammatory drug (NSAID)-photoinduced DNA damage in human peripheral blood mononuclear...Whereas Tiaprofenic Acid-photoinduced DNA damage was promptly induced (ie. observed at...

Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces...

Genetics;  July 1, 2008 ;   Conde, Francisco; San-Segundo, Pedro A;   787 words ......response to DNA injuries integrated by the DNA damage checkpoint; histone modifications play...silencing and the G^sub 1^/S and intra-S DNA damage checkpoints in vegetative cells. Here...does not result from reduced levels of DNA damage. Deletion of DOT1 partially or totally...

DNA Damage Checkpoints Are Involved in Postreplication Repair

Genetics;  December 1, 2006 ;   Barbour, Leslie; Ball, Lindsay G; Zhang, Ke; Xiao, Wei;   787 words ......endogenous cellular processes that can cause DNA damage and compromise the integrity of the genome...mechanisms that sense and respond to DNA damage. These surveillance mechanisms, knownasDNA...response to genotoxic treatments. The DNA damage checkpoint was initially discovered by...

A Point Mutation in the Aspergillus nidulans sonB^sup Nup98^ Nuclear Pore...

Genetics;  December 1, 2006 ;   De Souza, Colin P C; Hashmi, Shahr B; Horn, Kevin P; Osmani, Stephen A;   787 words ......demonstrate that this mutation causes marked DNA damage sensitivity at 42. Although SONBn^sup...transition, we demonstrate that the G^sub 2^ DNA damage checkpoint is functional in the sonB1...telomere maintenance. At 42 we find that the DNA damage response defect of sonB1 mutants ...

Photosensitized DNA Damage and its Protection via a Novel...

Photochemistry and Photobiology;  January 1, 2007 ;   Hiraku, Yusuke; Ito, Kimiko; Hirakawa, Kazutaka; Kawanishi, Shosuke;   787 words ......summarizes the mechanisms of UVA-induced DNA damage in the presence of various photosensitizers...chemoprevention. UVA radiation induces DNA damage at the 5'-G of 5'-GG-3' sequence in double-strand...oxygen (minor Type II mechanism), and DNA damage is induced by reactive species ...

Antagonism of Chk1 Signaling in the G^sub 2^ DNA Damage Checkpoint by...

Genetics;  September 1, 2006 ;   Calonge, Teresa M; O'Connell, Matthew J;   787 words ......Activation of the Chk1 protein kinase by DNA damage enforces a checkpoint that maintains...sub 2^ arrest/delay independently of DNA damage and upstream checkpoint genes. We utilized...exacerbates the defective response to DNA damage of cells lacking Chk1. We conclude that...

Genetic Interactions of the Aspergillus nidulans atmA^sup ATM^ Homolog...

Genetics;  February 1, 2008 ;   Malavazi, Iran; Lima, Joel Fernandes; de Castro, Patrícia Alves; Savoldi, Marcela; de Souza Goldman, Maria Helena; Goldman, Gustavo Henrique;   787 words ......functions as a central regulator of the DNA damage response in eukaryotic cells. In humans...addition to its expected role in the DNA damage response, we found that AtmA is also...investigating which components of the DNA damage response pathway are interacting with...

Effect of UVC-Induced Damage to DNA on the Intercalation of Thiazole...

Photochemistry and Photobiology;  May 1, 2007 ;   Trevithick-Sutton, Colleen C; Mikelsons, Larisa; Filippenko, Vasilisa; Scaiano, J C;   787 words ......drastic effect on a person's health (1). DNA damage can be caused by reactive oxygen species...to sunlight. In addition to studying DNA damage in humans, it is also of interest to...rapid screening methods for detecting DNA damage. The purpose of this report is to present...

Third DNA Damage Pathway Found.(Brief Article)(Editorial)

Genomics and Proteomics;  January 1, 2005 ;   Tolchin, Elizabeth;   263 words ......MAPKAP kinase-2 is a critical kinase for DNA damage response. When we discovered what its...which are known to be activated in the DNA damage repair process, he says. You could even...much more susceptible to dying following DNA damage. We show that the normal checkpoints...

Ccr4-Not Complex mRNA Deadenylase Activity Contributes to DNA Damage...

Genetics;  January 1, 2005 ;   Traven, Ana; Hammet, Andrew; Tenis, Nora; Denis, Clyde L; Heierhorst, Jörg;   787 words ...ABSTRACT DNA damage checkpoints regulate gene expression...turnover, have previously been linked to DNA damage responses, but it is unclear if this...deadenylase activity is required for DNA damage responses. However, ccr4k and caf1...

Does DNA Damage Cause Cancer?

The Scientist;  June 1, 2007 ;   Choi, Charles Q;   787 words ......initiating elements in the process. As DNA damage is often seen in fullblown tumors, its...revealed evidence that cellular responses to DNA damage, specifically to double-strand breaks...suppressor gene and other elements of the DNA damage-response pathway are so often inactivated...

DNA Damage in ^sup 131^I Treatment

The Journal of Nuclear Medicine;  February 1, 2007 ;   Anonymous;   161 words ......results showed a wide range in level of DNA damage among the patients. However, at the 54-day mark, the level of DNA damage in peripheral blood lymphocytes in...cases lower than that in controls. DNA damage in hot nodules persisted until the...

Application of single-cell gel electrophoresis (comet) assay for assessing...

The Journal of Nutrition;  June 1, 2002 ;   Heaton, Paul R; Ransley, Raymond; Charlton, Chris J; Mann, Sarah J; Et al;   787 words ......Comet) Assay for Assessing Levels of DNA Damage in Canine and Feline Leukocytes1 ABSTRACT...species in the development of oxidative DNA damage, the consequences of which have been...comet) assay for assessing levels of DNA damage in canine and feline leukocytes. Leukocytes...